In addition, the presence of pulmonary nodal disease, nodular granulomatous reaction, and sarcomatoid reaction have been reported in patients treated with anti-PD-1/anti-PD-L1 and anti-CTLA-4 inhibitors, and CIP should be considered for differentiation from such disease when chest imaging shows mediastinal or hilar lymph node enlargement or reticulonodular clouding (2). The gene discussed is CTLA4; the disease is hereditary sensory and autonomic neuropathy.