WiDr tumor cells have a higher cell surface expression of BTN3A1 compared to the WM9 and HAP1 cell lines, which could explain the higher killing percentage and significant increase of CD25 and CD69 on the challenged Vδ2 T cells because BTNs are well described stimulants of the Vδ2 TCR. The gene discussed is BTN3A1; the disease is neoplasm.