As displayed in Table 2, the number of CXCR5+TIM-3-PD-1+ T cells in paranasal sinus tissues, including mucosa and nasal polyps, was negatively correlated with the duration of CRS, i.e., in paranasal sinus mucosa, CD4+: r=-0.558, p=0.063; CD8+: r=-0.599, p=0.043; in nasal polyps, CD4+: r=-0.648, p= 0.035; CD8+: r=-0.411, p=0.21, respectively. The gene discussed is HAVCR2; the disease is Nasal polyposis.