Our correlation analysis results demonstrated that the percentage (r=-0.564, p=0.045) and number (r=-0.643, p=0.020) of CXCR5+TIM-3-PD-1+ CD8+ T cells in the nasal polyps of patients with CRS were negatively correlated with the LM score, which indicates the severity of disease (Figures 6E, F). The gene discussed is PDCD1; the disease is congenital rubella syndrome.