Furthermore, some natural products can inhibit immunosuppressive factor secretion: IL-10, TGF-β; promote anti-tumor factor secretion: IL-2, IL-5, IL-6, IL-12; reduce immunosuppressive immune cells: Treg, M2 microphage; increase anti-tumor CD8+ T-cells (253, 262, 263, 265, 273, 287, 292, 303, 304). Here, CD8A is linked to neoplasm.