demonstrated that IL-10 does not impact PD-L1 expression, while Gao et al.’s study found that IL-10 can inhibit IFN-γ-induced STAT1 phosphorylation in lung adenocarcinoma, thereby suppressing IFN-γ-induced upregulation of PD-L1 (128, 129). This evidence concerns the gene IL10 and lung adenocarcinoma.