However, another research suggested that IFN-γ upregulates PD-L1 expression in lung adenocarcinoma cells through the PI3K/AKT and JAK/STAT3 pathways, which need for further research support to prove the potential of STAT3 in IFN-γ induced PD-L1 expression (105). The gene discussed is CD274; the disease is lung adenocarcinoma.