Imprinted by the CD8 T-cell response during productive infection, the frequencies of viral epitope-specific CD8 T cells during latent infection remained in the rank order of mCMV-Δm152 >> mCMV-WT > mCMV-m152.IE+E, which is most pronounced for the known immunodominant epitopes IE1 and m164 in the H-2d haplotype (53, 61, 62) (Figure 3B, right panel). This evidence concerns the gene CD8A and disease arising from reactivation of latent virus.