Consistent with enhanced immune evasion, infection with the “super-evasion” virus mCMV-m152.IE+E resulted in an increased viral replication associated with a reduced CD8 T-cell response compared to WT virus and reciprocal to the data with mCMV-Δm152 at the end of the productive phase in the spleen at 8 weeks after syngeneic HCT (Figure 3A). Here, CD8A is linked to infection.