The result was clear and showed that the pool sizes of IE1 epitope-specific total CD8 T cells and the three activation subsets thereof were largely reduced during latent infection with mCMV-WT as well as with mCMV-Δm152 when cells of recipient-genotype did not express the presenting MHC-I molecule Ld (Figure 5B). The gene discussed is CD8A; the disease is disease arising from reactivation of latent virus.