Transcriptome analysis revealed that the expressions of IFNs (IFNA2, IFNA4, IFNA1, IFNA13, IFNB1, IFNL2 and IFNL3), ISGs (IFIT2, BST2, IRF7, OASL, MX1, IFITM1, IFIT2, IFI35, IFIH1, ISG15, CXCL10 and CXCL9) and pro-inflammatory cytokines (TNF, IL6, IL1B and IL1A) in skin from COVID-19 patients are significantly different from those of healthy donors (27). The gene discussed is IFIT2; the disease is COVID-19.