In a mouse model of transplantable sarcoma, the absence of NK cells induced neutrophils to acquire a pro-tumor phenotype characterized by the expression of VEGF-A (210) Interestingly, tumor-reprogrammed neutrophils that localize in a unique hypoxic and glycolytic niche exert a potent tumor-supporting, pro-angiogenic function through their high expression of VEGF-A (171). This evidence concerns the gene VEGFA and neoplasm.