Immunosuppressants ↑ (VEGF, MMP-2)MDSC recruitment ↑Treg population ↑CD8+ T cell killing ↓NK tumor surveillance ↓PD-L1 expression ↑Interferon Resistance ↑Immune stimulating cytokines ↓HIF-1 ↑ p53 ↓Macrophage crosstalk promoting WNT signaling ↑. The gene discussed is MMP2; the disease is neoplasm.