Additionally, from the perspective of the CD1d molecule itself, the activation of the CD1d is differentially regulated by endogenous/exogenous lipid ligands which are biosynthesized during obesity, or through the modulation of the CD1d signaling cascade, as indicated by reports suggesting that endogenous ligands switch on CD1d activation (28, 29). The gene discussed is CD1D; the disease is obesity due to melanocortin 4 receptor deficiency.