In multivariable analysis, considering DLBCL, HIV, and inflammation-related factors, age (HR = 2.873, 95% CI = 1.522–5.421, P = 0.001), LDH levels (HR = 2.421, 95% CI = 1.058–5.537, P = 0.036), the Hb/RDW ratio (HR = 2.645, 95% CI = 1.267–5.522, P = 0.010), and the CD4/CD8 ratio (HR = 2.151, 95% CI = 1.076–4.301, P = 0.030) remained independent predictors of clinical outcome (Table 2, Supplementary Figure 2). This evidence concerns the gene CD4 and diffuse large B-cell lymphoma.