In type-2 diabetes, pancreatic islet cell function declines due to chronic nonspecific inflammatory reactions including oxidative stress, endoplasmic reticulum stress, and mitochondrial dysfunction (Böni-Schnetzler and Meier, 2019), and the anti-inflammatory properties of GLP-1 receptor agonists improve islet cell function (Nauck et al., 2021). This evidence concerns the gene GLP1R and type 2 diabetes mellitus.