Having noted how GLP-1 receptor agonists enhanced the ER stress response in myocardial ischemia (Younce et al., 2013), kidney damage (Guo et al., 2017), cerebral infarction (Chien et al., 2015), and liver damage (Sharma et al., 2011), we decided to investigate the effects of exenatide, a GLP-1 receptor agonist capable of crossing the blood–brain barrier, in a rat model of SCI. This evidence concerns the gene GLP1R and myocardial ischemia.