AIFM1 and central nervous system cancer: Chiou et al. [44] conducted a study suggesting that danthron kills C6 rat glioma cells through the formation of reactive oxygen species, the collapse of mitochondrial transmembrane potential, and the release of cytochrome c, AIF, and Endo G. The study also showed that the apoptotic pathways driven by ROS and mitochondria were effective with danthron.