IGF1 and hypertensive disorder: Several studies have focused on the effects of aging and IGF-1 deficiency on adaptive vessel remodeling in response to hypertension, showing that adaptive hypertrophy and ECM remodeling in larger arteries and penetrating arterioles is impaired in aged and circulating IGF-1-deficient animals (Toth et al., 2013, 2014; Tarantini et al., 2017c; Fulop et al., 2019b).