IGF1 and cerebrovascular disorder: Data from humans and animal models indicate that decreased IGF-1 is associated with worsened cerebrovascular disease and signs of VCID (Gong et al., 2012; Muller et al., 2012; Ungvari and Csiszar, 2012; Sonntag et al., 2013; Tarantini et al., 2017c; Ungvari et al., 2017b).