For hyperthyroidism, as shown in the IVW-MR analysis, genetically proxied inhibition of HMGCR was significantly associated with a decreased risk in both the discovery dataset (OR, 0.417 per 1-mmol/L lower in LDL-C; 95% CI 0.262 to 0.664; P = 2.262 × 10-4) (Figure 3A) and the replication dataset (OR, 0.996; 95% CI 0.993 to 0.998; P = 0.002) (Supplementary Table S4). The gene discussed is HMGCR; the disease is hyperthyroidism.