ANGPTL3 and hypothyroidism: For hypothyroidism, genetically proxied ANGPTL3 inhibition demonstrated significant associations with a reduced risk in the discovery dataset (OR, 0.495 per 1-mmol/L lower in TG; 95% CI 0.308 to 0.796; P = 0.004) (Figure 3B), but this association did not replicate in the independent replication dataset (OR, 1.002; 95% CI 0.994 to 1.010; P = 0.638) (Supplementary Table S5).