As illustrated in Figure 4, genetic mimicry of LPL activation was significantly associated with the increased level of FT4 within reference range (β = 0.098; 95% CI 0.041 to 0.156; P = 0.001), partially supporting the observed detrimental effect of genetically proxied LPL activation on hyperthyroidism risk above. Here, LPL is linked to hyperthyroidism.