While no other significant results were observed in the discovery dataset for hyperthyroidism, the replication dataset indicated additional significant associations, including genetically proxied ANGPTL3 inhibition linked to a reduced risk of hyperthyroidism (OR, 0.995 per 1-mmol/L lower in TG; 95% CI 0.992 to 0.998; P = 0.002), and genetically proxied LPL activation associated with an increased risk of hyperthyroidism (OR, 1.003; 95% CI 1.001 to 1.005; P = 4.150 × 10-4). Here, ANGPTL3 is linked to hyperthyroidism.