Compared to our recent findings, the serum NPY levels of a historic population (21) with different types of non-traumatic intracranial hemorrhages (n = 66 patients with aneurysmal SAH and n = 13 patients with basal ganglia hemorrhage and cerebellar hemorrhage, respectively, undergoing a daily assessment of NPY concentrations in serum and CSF over a ten-day period after ictus) ranged significantly lower than our vascular group (p = 0.00013). This evidence concerns the gene NPY and intracranial hemorrhage.