STAT3 and Wiskott-Aldrich syndrome: Although serum immunoglobulin levels may not be low in combined immune defects like autosomal dominant STAT-3 loss of function, autosomal recessive DOCK-8 deficiency, or Wiskott Aldrich Syndrome (WAS), immunoglobulin replacement is still necessary in these disorders due to deficiency of functional antibodies and qualitative defects of immunoglobulins.