LRP11 and neoplasm: Notably, we found that the average methylation level of CpGs on the predominant form of the LRP11 promoter was significantly downregulated in the tumor group compared to its expression in the corresponding normal group (aggregation, p = 4.3e-13) (Figure 7B) and negatively correlated with the expression levels of LRP11 (aggregation, p = 1.9e-07) (Figure 7C), suggesting that the increase in LRP11 expression might be tightly regulated by promoter methylation.