As Jing et al. found that the mitochondrial Ca2+ signaling pathway mediated by the MCU regulator 1 in hepatocellular carcinoma could promote epithelial-mesenchymal transition via activating the ROS/nuclear factor erythroid 2-related factor 2 (Nrf2)/Notch1 pathway by sublethal levels of ROS(Jin et al., 2019). The gene discussed is NFE2L2; the disease is hepatocellular carcinoma.