SIRT1 and colorectal carcinoma: Analogously, when Yue et al. used the Sirtuin-1 inhibitor inauhzi to treat colorectal cancer (CRC), they demonstrated that inauhzi inhibited CRC by promoting acetylation of the MCU, which in turn enhanced mitochondrial Ca2+ uptake and caused mitochondria calcium overload (Sun et al., 2022).