SCN1B and Febrile seizure (within the age range of 3 months to 6 years): Previous work from the Petrou group characterized the variant SCN1B-p.C121W in transgenic mice59; however, this variant is associated with genetic epilepsy with febrile seizures plus (GEFS+) in monoallelic patients and has not yet been reported in a biallelic patient with DEE52.