Kong LQ et al. also reported that mtDNA leakage after middle cerebral artery occlusion promotes M1 polarization of microglial cells through cGAS-STING signaling, and verified the reduction of cerebral infarct size and recovery of neural function by knockout of STING (Kong et al., 2022) (Summarized in Figure 2). This evidence concerns the gene STING1 and brain infarction.