This involvement is through the NLRP3/Caspase-1 pathway, where NLRP3 expression negatively impacts the number or function of glutamate receptors and age-related cognitive functions of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, leading to synaptic plasticity and cognitive decline (Wang et al., 2022). This evidence concerns the gene NLRP3 and Mental deterioration.