NPY1R and early-onset autosomal dominant Alzheimer disease: It is particularly noteworthy that the NPY1R agonist has shown promising results in rescuing impaired learning and memory in a rat model of Alzheimer’s disease (Rangani et al., 2012) However, it’s important to highlight that, despite these promising results in pathological models, there is currently limited evidence to suggest a similar impact of NPY1R agonists on learning and memory under physiological conditions.