CLEC7a is also upregulated by microglia in mouse models of experimental autoimmune encephalomyelitis (Krasemann et al., 2017; Deerhake et al., 2021), with Clec7a–/– mice displaying more severe disease, although these effects were more likely mediated by CNS-infiltrating myeloid cells than microglia (Deerhake et al., 2021). The gene discussed is CLEC7A; the disease is experimental autoimmune encephalomyelitis.