Moreover, a small population of CD11b+CD45high mononuclear phagocytes has been identified by flow cytometry in the surroundings of Aβ plaques in the 5XFAD mouse model of Alzheimer’s disease (AD) pathology, and these cells exhibit transcriptional similarities to DAM, such as upregulation of Trem2 and Cd11c (Rangaraju et al., 2018). This evidence concerns the gene TREM2 and Alzheimer disease.