SHOX and Leri-Weill dyschondrosteosis: In this study, both X-linked and Y-linked short stature homeobox-containing (SHOX) gene mutations were identified in the Leri-Weill dyschondrosteosis (LWD) affected family, suggesting a de novo event of X–Y pseudo-autosomal homologous recombination during sperm meiosis in the common ancestor of the affected family members.