These results indicate that the activation of PKCδ and FOXM1 is essential for Wnt/β‐catenin signaling and suggest a mechanism by which NC114 suppresses Wnt/β‐catenin signaling via inhibition of FOXM1 and β‐catenin nuclear translocation through inactivation of PKCδ and MEK/ERK signaling in SW480 and HCT‐116 colorectal cancer cells. The gene discussed is FOXM1; the disease is colorectal cancer.