The major findings of our study were (1) FABP4, ANGPTL3, and ANGPTL4, as pro‐inflammatory factors, were independent predictors for CAD; (2) the association between ANGPTL3 and CAD was significantly affected by hypertension and there may be interaction between ANGPTL3 and hypertension. Here, ANGPTL4 is linked to coronary artery disorder.