The AUC of the ANGPTL3 > 67.53 ng/mL and ANGPTL4 > 29.95 ng/mL combination for diagnosing CAD was 0.728, the diagnostic efficiency was improved, and the specificity was high, indicating that the combination of ANGPTL3 > 67.53 ng/mL and ANGPTL4 > 29.95 ng/mL had better value in excluding CAD. The gene discussed is ANGPTL3; the disease is coronary artery disorder.