Moreover, apart from CS, many other enzymes participating in citrate metabolism towards de novo fatty acids synthesis are upregulated in pancreatic ductal adenocarcinoma, including ATP citrate lyase (ACLY), fatty acid synthase (FASN), stearoyl‐CoA desaturase (SCD1) and 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase (HMGCR) [9]. The gene discussed is ACLY; the disease is pancreatic ductal adenocarcinoma.