MBP and myeloid sarcoma: To conclude, in this study we highlight an exacerbation of the pathological hallmarks which we previously spotted in the NAWM of MS brains,5 showing that, via an (i) increase of posttranslational myelin modifications (which are likely specific for prelesional stages of MS WM, Fig. 6C), (ii) myelin blister enhancement and (iii) microglia‐directed response toward citrullinated MBP, the NAWM might encounter a degenerative evolution toward microscopic diffusivity, here dubbed as mDAWM.