Accordingly, there is growing interest in understanding the diuretic and natriuretic properties of contemporary medical therapies such as sodium glucose cotransporter 2 (SGLT2) inhibitors, carbonic anhydrase (CA) inhibitors, thiazide diuretics, and mineralocorticoid receptor (MR) antagonists, and their roles in managing volume overload in HF, especially as adjuncts to loop diuretic therapy. Here, NR3C2 is linked to hydrops fetalis.