Neurohormonal activation, including increased plasma levels of norepinephrine, angiotensin II, and vasopressin, characterizes an early physiological manifestation contributing to sodium and bicarbonate (HCO3) retention in HF by upregulating SGLT2, Na-HCO3, and NHE3 activity in the proximal tubule [13]. This evidence concerns the gene SLC5A2 and hydrops fetalis.