STAT3 and colorectal carcinoma: In this study we aim to elucidate the therapeutic potential of inhibiting signal transduction using 3 repurposed JAKi in recapitulative disease models. We subsequently aim to establish a prognostic relationship of JAK/STAT3 expression relative to TSP in 3 retrospective CRC cohorts complemented by multi-omic interrogation of the impact of JAK/STAT3 overexpression.