After detecting the expression of EMT and metalloproteinase-related genes in lung adenocarcinoma cells co-cultured with M2-like macrophages, we found that the expression of EMT-related genes (E-cadherin, N-cadherin, Snail, Vimentin) was highly variable (Fig. S7a). The gene discussed is SNAI1; the disease is lung adenocarcinoma.