In addition, we have provided strong evidence that the JAK2/STAT3/C/EBPβ-induced IL-6 positive feedback pathway is important for lung cancer cell growth, migration, and invasion, which suggests that the STAT3-C/EBPβ-IL-6 signaling axis plays a crucial role in TAM-mediated lung cancer progression. The gene discussed is JAK2; the disease is lung carcinoma.