In the nomogram, age at diagnosis, menopausal status, tumor size, personal history of BC, personal history of other BRCA-related cancers, family history of BC, histological type, lymph node status, ER status, Ki67 status, and HER-2 status were all independent predictors of BRCA mutations in BC patients (Fig. 4). The gene discussed is ERBB2; the disease is breast cancer.