Among the most highly downregulated in ATLL, miR-let-7a, miR-16, miR-20, miR-21, miR-31, miR-93, miR125a, miR-132, miR-143, miR-155, miR-200 and miR-873, HBZ had a direct involvement through the dysregulation of the Dicer promoter [182]. Here, HBZ is linked to adult T-cell leukemia/lymphoma.