Recently, pre-clinical studies from our group have demonstrated that the normalization of hyperglycemia by glucagon-like receptor 1 (GLP-1R) activation or by dipeptidyl peptidase-4 (DPP-4) inhibition in the chronic, post-acute phase after stroke was associated with improved post-stroke functional recovery in obese/diabetic mice [15, 16]. The gene discussed is DPP4; the disease is Stroke.