Using age-based PSA thresholds, 19.8% (95% confidence interval (CI):19.4%, 20.2%) of White men with a raised PSA had a diagnosis of prostate cancer in the following year, compared with 13.4% (95% CI:12.2%, 14.7%) of Asian men and 24.7% (95% CI:23.3%, 26.2%) of Black men. Here, KLK3 is linked to Familial prostate cancer.