We found that the increased number of Ly6Clow macrophages in CD244fl/flLysMcre mice was accompanied by a significant upregulation of anti-tumorigenic macrophage markers and cytokines, including CD80 (Fig. 4A), NOS2, IL6, and IFNB1 (Fig. 4B), in CD11b+ sorted tumor-infiltrating macrophage populations. This evidence concerns the gene NOS2 and neoplasm.