Similarly, we also found a lower frequency of CXCR5+ Tfh (Fig. 2B, C) while a higher frequency of CXCR5+ICOS+ Tfh (Fig. 2E, F) and CXCR+ICOS+PD-1+ Tfh (Fig. 2I, J) in children with allergic asthma. Here, ICOS is linked to allergic asthma.