The frequency of CD19+ B cells (Fig. 1A, B), CD27+ memory B cells (Fig. 1C, E), CD24hiCD27− B cells (Fig. 1G, I), CD24+CD27− B cells (Fig. 1H, I), CD24hiCD38hi transitional B cells (Fig. 1J, M), CD24intCD38int B cells (Fig. 1K, M), CD27+CD38+ plasmablasts (Fig. 1N, Q) and CD27−CD38− B cells (Fig. 1P, Q) were significantly increased while the frequency of CD27− naïve B cells (Fig. 1D, E), CD24hiCD27+ B cells (Fig. 1F, I), CD24hiCD38− B cells (Fig. 1L, M) and CD27+CD38− B cells (Fig. 1O, Q) were significantly decreased in children with allergic asthma. The gene discussed is CD19; the disease is allergic asthma.