Expansion of CXCR5− Tph, CXCR5−ICOS+ Tph, CXCR5−ICOS+PD-1+ Tph, CXCR5+ICOS+ Tfh and CXCR+ICOS+PD-1+ Tfh cells and skewing to Tph2, Tph17, Tfh2 and Tfh17 subtypes in patients with allergic asthma. This evidence concerns the gene TPH2 and allergic asthma.