Serum total IgE level positively correlate with CD27+CD38+ plasmablasts, CD24hiCD38hi transitional B cells, CXCR5− Tph, CXCR5−ICOS+PD-1+ Tph, Tph2 and Tfh2 subtypes in children with allergic asthma. The gene discussed is TPH1; the disease is allergic asthma.