Dysregulation of the Hippo pathway and hyperactivation of YAP/TAZ are common traits observed in most CRC patients and are fueled by multiple mechanisms including crosstalk with Wnt/β-catenin pathway [128], recurrent Adenomatous Polyposis Coli (APC) loss-of function mutations [127] and deregulation of inhibitory pathways [129–132]. This evidence concerns the gene YAP1 and colorectal carcinoma.