Evidence from in vitro and in vivo models indicates that REG-γ sustains colon inflammation enhancing cancer susceptibility by two mechanisms: (i) overactivation of YAP mediated by LATS1 degradation; and (ii) modulation of the positive feedback loop between YAP and Nuclear factor-kappa B (NF-κB), a master regulator of inflammation [143]. This evidence concerns the gene YAP1 and cancer.