The results of the univariate analysis of indicate that ADL decline group exhibited significantly association between disease severity scores (WHO6; OR 4.56, 95%CI 1.93–10.62), frailty(OR 9.40, 95%CI (3.24–39.95)), cognitive impairment (OR 4.71, 95%CI 2.58–8.59), CCI (OR 1.12, 95%CI 1.01–1.23), length of stay(OR 1.08, 95%CI 1.04–1.13), lymphocyte count (OR 0.60, 95%CI 0.37–0.93), hemoglobin (OR 0.98,95%CI 0.07–0.99), and albumin (OR 0.92,95%CI 0.87–0.97). This evidence concerns the gene ALB and Cognitive impairment.