In a binomial logistic regression model including the preoperative BChE activity, age, preoperative MoCA-score, history of coronary heart disease and type 2 diabetes mellitus, significantly higher odds for the development of POD could be found for patients with coronary heart disease (OR = 4.371 (95% CI: 1.502 to 12.721), p = 0.007). This evidence concerns the gene BCHE and type 2 diabetes mellitus.