We also analyzed the expression of markers and suppressor genes associated with exhausted CD8 + T cells, including PD-1, PD-L1, and CD244, between SQCC and ADC lesions (Figure Supplementary 2) and found no significant difference in PD-1, PD-L1, and CD244 expression between both groups (p > 0.05). Here, CD8A is linked to AIDS dementia complex.