Although the role of cGAS, STING and cytokines in the severity of COVID-19 has been described in other populations, our study includes initial information on the relationship among these components in the population of Brazil, more specifically, in the population of the Brazilian Amazon, a mixed-race population (consisting of whites, blacks and indigenous people)37 that presents genetic and cultural differences compared to populations evaluated in other studies. This evidence concerns the gene STING1 and COVID-19.