RIGI and infection: Although the major IFN expression-inducing pattern recognition receptors (PRRs) that detect viral RNAs are members of the retinoic acid-inducible gene I (RIG-I) and Toll-like receptor (TLR) protein families, STING also plays an important role in RNA virus infection16 and has been associated with infections by vesicular stomatitis virus, dengue virus, coronavirus, and influenza virus.