The opposite change was observed in CST1 knockdown ESCC cell KYSE150, exhibiting a mitoATP/glycoATP ratio of 0.9:1, significantly lower than 1.3:1 in the NC group as well as a significant decrease of ATP level as compared with that in the NC group (Fig. 3B–D). Here, CST1 is linked to esophageal squamous cell carcinoma.