This is consistent with studies that showed only a minor reduction in γ-tubulin signal at centrosomes in CDK5RAP2 knockout cells62,63 and that homozygous mutations in the CDK5RAP2-encoding gene in humans are not lethal, though they cause developmental disorders such as microcephaly and Seckel syndrome, probably due to perturbations of cell division64,65. Here, CDK5RAP2 is linked to Seckel syndrome.