Kimbung et al. reported that patients with high tumor expression of CYP27A1, the enzyme converting cholesterol to 27-HC, were less likely to receive endocrine treatment (OR = 0.62 (0.45–0.87))12, however, comparison between circulating 27-HC and tissue content are difficult as associations were reported to be weak (r = 0.029)36. The gene discussed is CYP27A1; the disease is neoplasm.