First of all, referring to the PCOS related genes in Ovarian Kaleidoscope Database (OKdb) and LncRNA2Target, there were 8 overlapped genes, including ABCA1, CCL2, CD36, HMGB1, MAPK1, MIR206, MIR21 and MIR429 (Fig. 5A). This evidence concerns the gene HMGB1 and polycystic ovary syndrome.