CALR and infection: Proteins such as tryparedoxin peroxidase, elongation factor 1-alpha and 2, histones H4, H2A and H2B, calreticulin and heat shock protein 70 and 85 increased in LEVs of myoblasts (C2C12) with T. cruzi in the first 2 h of infection, but decreased after 24 h (Fig. 4A).