Inhibition of NRF2 in cancer cells has been reported to suppress HIF activity through multiple molecular events, including direct regulation of HIF-1α expression by NRF2, HIF-1α stabilization by the NRF2 target NQO1 and TRX1, and HO-1-driven CO and miRNA expression58,59,61,65,66. Here, HIF1A is linked to cancer.