TRBC2 and T-cell and NK-cell neoplasm: Moreover, we show that dual TRBC1/2 staining is needed for the accurate determination of TRBC isoform expression in the context of emerging TRBC1/2-targetted therapies, as 69% of T-cell neoplasms incorrectly interpreted as TRBC1-dim on single staining were shown to be TRBC2-restricted on dual TRBC1/2 staining (Fig. 6D–F).