RRBP1 and acute lymphoblastic leukemia: On all 60 cases involved by T-cell malignancy, expert gating showed a neoplastic subset exhibiting either a clonal TRBC2:TRBC1 ratio (52 cases, 87%)(Fig. 4A–D), or aberrant loss of both surface and cytoplasmic TRBC expression (8 cases, 13%: 4 T-ALL, 2 CTCL, 1 PTCL, and 1 L-HES) (Fig. 4E).