The features of these small subsets were similar to those previously described for T-cell clones of uncertain significance [17], including mostly CD8+ phenotype (72%), lack of overt tumor-specific immunophenotypic abnormalities, and much smaller median clone size than malignant T-cell subsets (median: 4.7 vs. 69% of lymphocytes, p < 0.0001, Fig. 5B). The gene discussed is CD8A; the disease is neoplasm.