Moreover, LNP-CAD9 co-delivering Cas9 mRNA/VEGFR2 single guide RNA (sgRNA) effectively induced VEGFR2 knock out in lung endothelial cells of female mice at a dose of 4.0 mg kg−1 and thus demonstrated significant therapeutic potential in antiangiogenic therapy for suppressing tumor growth within a lung tumor model, outperforming a gold standard lung-tropic MC3/DOTAP LNP system. The gene discussed is KDR; the disease is neoplasm.