KDR and neoplasm: Furthermore, evaluations of the tumor area per lung and histological examinations via hematoxylin and eosin (H&E) staining showed that the administration of LNP-CAD9 co-delivering Cas9 mRNA/VEGFR2 sgRNA led to a significant reduction in lung tumor burden, outperforming MC3/DOTAP LNP treated groups (Fig. 5d, e).